Synthetic DNA is a powerful tool for various applications in biotechnology, medicine, and data storage. However, synthesizing DNA with high quality, accuracy, and efficiency is not an easy task. That’s why Twist Bioscience has developed a revolutionary silicon-based DNA synthesis platform that offers precision at a scale otherwise unavailable to our customers.

What is Twist Bioscience’s Silicon-Based DNA Synthesis Platform?

Twist Bioscience’s platform uses a proprietary silicon chip that can synthesize thousands of oligonucleotides (short DNA fragments) in parallel. These oligonucleotides are then assembled into longer DNA sequences, such as genes, variant libraries, or oligo pools. The silicon chip allows for a high-density and low-cost synthesis process, resulting in faster and more affordable production of synthetic DNA.

What are the Benefits of Using Twist Bioscience’s Synthetic DNA Products?

Twist Bioscience offers a range of synthetic DNA products that can help you with your research needs, such as:

  • Genes: Twist Bioscience can synthesize any gene sequence up to 3.2 kb in length, with an average turnaround time of 10 days and an error rate of less than 1 in 10,000 base pairs. You can order genes online or use Twist’s Gene Designer tool to optimize your gene sequence for expression, codon usage, GC content, and restriction sites.
  • Oligo Pools: Twist Bioscience can provide you with custom pools of oligonucleotides that can be used for CRISPR genome editing, multiplex PCR, or other applications. You can order oligo pools with up to 300,000 oligos per pool, with lengths ranging from 40 to 300 bases and a uniformity of over 90%.
  • Variant Libraries: Twist Bioscience can create libraries of gene variants that can be used for protein engineering, antibody discovery, or drug development. You can order variant libraries with up to 10^13 variants per library, with full control over the position and type of mutations. You can also use Twist’s Library Designer tool to design your library based on your desired diversity and coverage.
  • DNA Data Storage: Twist Bioscience can encode digital data into synthetic DNA molecules that can be stored for long-term preservation. DNA data storage is a secure, durable, and compact way of storing large amounts of information that can be retrieved by sequencing the DNA. Twist Bioscience has partnered with Microsoft and the University of Washington to demonstrate the feasibility of this technology.
  • NGS Target Enrichment: Twist Bioscience can provide you with custom probes that can capture specific regions of interest from complex genomic samples for next-generation sequencing (NGS). This can improve the sensitivity and specificity of your NGS analysis and reduce the cost and time of sequencing. Twist Bioscience offers both human and non-human target enrichment solutions.

How Can You Get Support from Twist Bioscience?

Twist Bioscience has a dedicated technical support team that is available to help you with your research challenges. Whether you need assistance with designing your synthetic DNA product, optimizing your experimental protocol, or troubleshooting your results, Twist Bioscience’s experts are ready to answer your questions and provide guidance. You can contact them by phone, email, or online chat.

If you are interested in ordering synthetic DNA products from Twist Bioscience, you can visit their website and create an account. You can then browse their product catalog and place your order online. You can also request a quote or a consultation from their sales team. Twist Bioscience accepts various payment methods, such as credit card, wire transfer, or purchase order.

Also Read: How Adept Can Help You Achieve Your Goals With Natural Language